Competitive repopulation in unirradiated normal recipients.
نویسنده
چکیده
منابع مشابه
Ultimate erythropoietic repopulating abilities of fetal, young adult, and old adult cells compared using repeated irradiation
Erythropoietic repopulating abilities of fetal liver cells and young and old adult marrow cells were compared as follows: Equal numbers of cells from a donor of each age were mixed with a constant portion of cells pooled from genetically distinguishable competitors. These mixtures were transplanted into stem cell-depleted recipients, and the proportions of recipient hemoglobin that were donor t...
متن کاملUnaltered repopulation properties of mouse hematopoietic stem cells transduced with lentiviral vectors.
Recent studies of retroviral-mediated gene transfer have shown that retroviral integrations themselves may trigger nonmalignant clonal expansion of hematopoietic stem cells (HSCs) in transplant recipients. These observations suggested that previous conclusions of HSC dynamics based on gamma-retroviral gene marking should be confirmed with improved vectors having a more limited capacity to trans...
متن کاملLong-term erythropoietic repopulating ability of old, young, and fetal stem cells
It is possible that erythropoietic stem cells do not age. This would mean that stem cells from old donors can function as well as those from young or fetal donors. The competitive repopulation assay has been used to test long-term stem cell function by directly comparing how well competing stem cells repopulate a recipient and produce differentiated cell types. C57BL/6J (B6) mice were used as d...
متن کاملFractionation of mouse bone marrow by adherence separates primitive hematopoietic stem cells from in vitro colony-forming cells and spleen colony-forming cells.
Fractionation of mouse bone marrow by adherence to tissue culture plastic was used to characterize the adhesive properties of hematopoietic stem (HS) cells capable of long-term reconstitution. The adherent fraction that represents approximately 13% of the total marrow population was virtually devoid of in vitro colony-forming cells and spleen colony-forming cells but did contain approximately 3...
متن کاملThe Repopulation Potential of Fetal Liver Hematopoietic Stem Cells in Mice Exceeds That of Their Adult Bone Marrow Counterparts
Varying, limiting numbers of unseparated or purified cells (Ly-5.1). either from 14.5-day-old fetal liver (FL) or from adult bone marrow (BM) were coinjected with I O 5 unseparated BM cells (Ly-5.2) into lethally irradiated adult C57B1/6 recipients (Ly-5.2). The kinetics of donor cell repopulation of the lymphoid and myeloid compartments by Ly-5.1’ donor hematopoietic stem cells (ie, competitiv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Blood
دوره 81 10 شماره
صفحات -
تاریخ انتشار 1993